Platelet-Activating Factor Acetylhydrolase Concentration in Children With Abdominal Obesity
نویسندگان
چکیده
منابع مشابه
Platelet-activating factor acetylhydrolase concentration in children with abdominal obesity.
Concentration in Children With Abdominal Obesity To the Editor: In human obesity, increased oxidant stress is an important factor in the development of atherosclerosis.1 Oxidation of the lipid components of low-density lipoprotein (LDL) is causative, because oxidized LDL contributes to many of the stages of progression of atherosclerosis. In particular, small dense LDL particle, which is freque...
متن کاملHuman Plasma Platelet-activating Factor Acetylhydrolase
Human plasma platelet-activating factor (PAF) acetylhydrolase hydrolyzes the sn-2 acetyl residue of PAF, but not phospholipids with long chain sn-2 residues. It is associated with low density lipoprotein (LDL) particles, and is the LDL-associated phospholipase A, activity that specifically degrades oxidatively damaged phospholipids (Stremler, K. E., Stafforini, D. M., Prescott, S. M., Zimmerman...
متن کاملHuman plasma platelet-activating factor acetylhydrolase.
Platelet-activating factor (PAF, 1-0-alkyl-2-acetylsn-glycero-3-phosphocholine) is a biologically active phospholipid synthesized by a variety of cell types upon appropriate stimulation. PAF is a potent hypotensive factor and it activates platelets and inflammatory cells at concentrations as low as 10”’ M. Removal of the acetyl moiety at the sn-2 position abolishes the biological activity and t...
متن کاملPlatelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness.
Platelet-activating factor acetylhydrolase was analyzed in cerebrospinal fluid samples taken from children with a variety of neurological conditions (85 patients; mean age, 3.8 years) to determine it is involved in the defense mechanism against the toxic effect of inflammatory mediators in the central nervous system. A significant increase in cerebrospinal fluid activity was seen in the patient...
متن کاملDifferential expression of platelet-activating factor acetylhydrolase in lung macrophages.
Platelet-activating factor (PAF) acetylhydrolase plays a crucial role inactivating the potent inflammatory mediator, PAF. PAF is implicated in the initiation and propagation of acute lung injury. Although PAF acetylhydrolase is a constitutively active plasma protein, increased PAF production during inflammatory events may necessitate an increase in PAF acetylhydrolase activity in the local envi...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2006
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000217284.86123.2c